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Also, Patients UN agency are opioid-tolerant are those receiving, for one week or longer, a minimum of sixty mg oral opiate per day. Twenty five metric weight unit percutaneous opiate per hour. Thirty mg oral oxycodone per day. Eight mg oral hydromorphone hydro-chloride per day. twenty five mg oral oxymorphone per day, or associate degree equianalgesic dose of another opioid.