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Quantity Needed to Kill The estimated lethal dose (LD50) of botulinum toxin is about 1-2 nanograms per kilogram of body weight for humans when inhaled, and even less when injected. This means that less than a microgram can potentially be fatal to an adult. Signs and Symptoms Symptoms of botulinum toxin poisoning include: Initial Symptoms : Double vision, drooping eyelids, and facial weakness.