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Also, like THC , prolonged usage of synthetic cannabinoids may increase one's disposition to mental illness and psychosis [11] , particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia). [12] [13] As synthetic cannabinoids are active in the milligram range (with below 5mg being a common dose), it is important to use proper precautions when dosing to avoid a negative experience.