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Of the approximately 170 substances reported since 1997 by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), over half have appeared since 2006. [5] Toxicity and harm potential The safety profile of research chemicals is generally unknown due to a lack of medical studies. There is little to no information on the toxicity, negative health risks, long-term side effects, or lethal dosage of these chemicals, which make their use riskier than the use of more common,...