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Moreover, Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue-colored lips, or if you are hard to wake up. Common Opana side effects may include: dizziness, drowsiness; headache, tiredness; or stomach pain, nausea, vomiting, and constipation.