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It was created by Daniel Lednicer at Upjohn in the 1970s.[1] Initial studies assessed that it was around 10,000 times the quality of morphine in creature models.[2] However, later studies doled out an estimation of 504 times the strength of morphine for the more dynamic trans-isomer.[3] To date, it is obscure if this medication has been utilized by people, nonetheless, it was seized alongside three kilograms of acetylfentanyl in an April 25, 2013 police activity in Montreal, Canada.