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If you snort ketamine, we advise to start with a dose between 20 milligrams and 50 milligrams. First time? Start with 20 milligrams and wait for at least 15/20 minutes to see what kind of effect you experience. RISKS: – Ketamine has an anaesthetic effect, so you might injure yourself without noticing it; – Nausea and vomiting; – Disorientation and reduced motor skills; – Possible kidney and bladder problems; – Addiction.