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Internationally, heroin is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs, and it is generally illegal to make, possess, or sell without a license. About 448 tons of heroin were made in 2016. In 2015, Afghanistan produced about 66-percent of the world's opium. Illegal heroin is often mixed with other substances such as sugar, starch, quinine, or strychnine.